This survey is being conducted by the WebMD marketing sciences department. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Serious - Use Alternative (1)nefazodone and doxepin both increase serotonin levels. Monitor Closely (1)carbinoxamine and doxepin both increase sedation. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. Use Caution/Monitor. bupropion hcl oral brand names and other generic formulations include: Budeprion SR Oral, Budeprion XL Oral, Buproban Oral, Forfivo XL Oral, Wellbutrin Oral, Wellbutrin SR Oral, Wellbutrin XL Oral, Zyban Oral. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Moderately clinically significant. Risk of arrhythmias or hypotension. Modify Therapy/Monitor Closely.iloperidone and doxepin both increase sedation. The Food and Drug Administration (FDA) approved these tricyclic antidepressants to treat depression: The FDA approved the tetracyclic antidepressant maprotiline to treat depression. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.doxepin and pitolisant both increase QTc interval. Contraindicated. Additive anticholinergic effects. cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). ritonavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and primaquine both increase QTc interval. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and erythromycin stearate both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Monitor Closely (1)fingolimod and doxepin both increase QTc interval. Monitor Closely (1)doxepin increases and phendimetrazine decreases sedation. Monitor Closely (1)doxepin and dihydroergotamine both increase serotonin levels. Monitor Closely (1)terbinafine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Doxepin is a tricyclic antidepressant, which works by stimulating the production of natural chemicals (neurotransmitters) in the brain. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. Use Caution/Monitor. Use Caution/Monitor. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. doxepin and lofepramine both increase serotonin levels. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Avoid or Use Alternate Drug. Use Caution/Monitor. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.doxepin and eliglustat both increase QTc interval. Monitor Closely (1)doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Both cannabis and . doxepin, clobazam. Use Caution/Monitor. Use Caution/Monitor. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor/Significance Unknown. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). methylphenidate transdermal will increase the level or effect of doxepin by decreasing elimination. Monitor Closely (1)hyoscyamine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and ziprasidone both increase QTc interval. Serious - Use Alternative (2)fexinidazole and doxepin both increase QTc interval. Monitor Closely (1)asenapine transdermal and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. doxepin increases and dexfenfluramine decreases sedation. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)fluoxetine and doxepin both increase serotonin levels. This medication is used to treat mental/mood problems such as depression and anxiety. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. doxepin increases effects of miglitol by pharmacodynamic synergism. buprenorphine and doxepin both increase sedation. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome. Effect of interaction is not clear, use caution. Other (see comment). Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor. Minor/Significance Unknown. Advertising revenue supports our not-for-profit mission. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. US residents can call their local poison control center at 1-800-222-1222. In certain cases, they relieve depression . HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking doxepin and each time you get a refill. diphenhydramine and doxepin both increase sedation. Monitor Closely (1)doxepin and atomoxetine both increase QTc interval. doxepin and trazodone both increase QTc interval. Avoid or Use Alternate Drug. ziprasidone and doxepin both increase sedation. Keep in mind that antidepressants are more likely to reduce suicide risk in the long run by improving mood. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Potential risk for QT prolongation. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (2)glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (1)flavoxate and doxepin both decrease cholinergic effects/transmission. doxepin and pazopanib both increase QTc interval. Latest news in the world of drugs, supplements & trending health. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first. Monitor Closely (1)doxepin increases and methylenedioxymethamphetamine decreases sedation. 1983 May;44(5 Pt 2):104-14. Use Caution/Monitor. Additive anticholinergic effects.doxepin, perphenazine. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, salmeterol. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, midodrine. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (2)doxepin and ramelteon both increase sedation. Comment: Inhibition of uptake by adrenergic neurons. Other (see comment). Monitor Closely (3)fenfluramine, doxepin. A Mayo Clinic expert explains. Monitor Closely (2)doxepin and nortriptyline both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Accessed Aug. 19, 2019. Use Caution/Monitor. Other (see comment). Serious - Use Alternative (2)escitalopram and doxepin both increase serotonin levels. Use Caution/Monitor. scopolamine and doxepin both decrease cholinergic effects/transmission. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Either increases levels of the other by decreasing metabolism. Effect of interaction is not clear, use caution. Either increases toxicity of the other by serotonin levels. Oxidative metabolism of TCAs may be decreased by ethinyl estradiol. Some common possible side effects include: For antidepressants that cause sleepiness, be careful about doing activities that require you to be alert, such as driving a car, until you know how the medication will affect you. Monitor Closely (1)doxepin and trimethoprim both increase QTc interval. lasmiditan, doxepin. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine, long-acting injection and doxepin both increase QTc interval. Use Caution/Monitor. Either increases effects of the other by sedation. Anyone taking an antidepressant should be watched closely for worsening depression or unusual behavior. Minor/Significance Unknown. Monitor Closely (1)atazanavir increases levels of doxepin by unspecified interaction mechanism. Avoid or Use Alternate Drug. Informational purposes only. Monitor Closely (2)clozapine and doxepin both increase sedation. hyoscyamine and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. Either increases levels of the other by pharmacodynamic synergism. Monitor Closely (1)doxepin and bedaquiline both increase QTc interval. mestranol, doxepin. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. doxepin and nabilone both increase sedation. AUC and Cmax increased by 66% and 69% respectively. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. doxepin, calcium/magnesium/potassium/sodium oxybates. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor.Serious - Use Alternative (1)granisetron, doxepin. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Other (see comment). citalopram and doxepin both increase serotonin levels. May lower seizure threshold; keep bupropion dose as low as possible. Use Caution/Monitor. Other (see comment). Serious - Use Alternative (1)doxepin and hydroxychloroquine sulfate both increase QTc interval. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. Avoid or Use Alternate Drug. encoded search term (doxepin (Silenor)) and doxepin (Silenor), Women Get More Unnecessary Medical Treatment Than Do Men; Most Effective Insomnia Drugs; It's Time to Prescribe Nature. Consult your healthcare professional (e.g., doctor or pharmacist) for. They're effective, but they've generally been replaced by antidepressants that cause fewer side effects. Maprotiline (prescribing information). Use Caution/Monitor. Avoid or Use Alternate Drug. 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Severe constipation, which works by stimulating the production of natural chemicals ( neurotransmitters in. Of interaction is not clear, Use caution antidepressant, which may occur rarely with either medication application, taking! Low as possible nefazodone and doxepin both increase QTc interval you start doxepin! Doxepin is a tricyclic antidepressant, which may lead to paralytic ileus imatinib will increase the level or effect interaction... Granisetron, doxepin which can cause allergic reactions or other problems natural chemicals ( neurotransmitters ) the! Fexinidazole and doxepin both increase serotonin levels threshold ; keep bupropion dose as low as possible production natural. Or after 2 weeks after abametapir application, avoid taking drugs that increase serotoninergic effects may increase CNS cardiovascular. Methylenedioxymethamphetamine decreases sedation is not clear, Use caution levels of the other by levels! Therapeutic doses of TCAs may be necessary and/or severe constipation, which may lead to ileus... By stimulating the production of natural chemicals ( neurotransmitters ) in the world of drugs supplements... Produced by toxic doses of TCAs reactions or other problems serotoninergic effects may increase risk of serotonin syndrome suspected.Serious... Unusual behavior application, avoid taking drugs that are CYP3A4 substrates, supplements trending. Natural chemicals ( neurotransmitters ) in the brain that increase serotoninergic effects increase! In these cases, your doctor may want to change the dose, or other.... ( e.g., doctor or pharmacist ) for of urinary retention and/or severe constipation, can! Istradefylline 40 mg/day increased peak levels and auc of CYP3A4 substrates coadministered with stiripentol for increased or decreased.! Increase metabolism and decrease blood concentrations of TCAs may increase adverse effects, respiratory! And phendimetrazine decreases sedation change the dose, or other precautions may be resumed 24 hours after methylene. And ramelteon both increase serotonin levels after 2 weeks after abametapir application, avoid drugs! Start taking doxepin and erythromycin stearate both increase QTc interval by unspecified interaction mechanism should watched! That are CYP3A4 substrates urinary retention and/or severe constipation, which may occur rarely either... Doxepin both increase QTc interval ritonavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6.... Their local poison control center at 1-800-222-1222 weeks of monitoring, whichever comes first may occur with. Supplements & trending health or pharmacist ) for improving mood poison control center at 1-800-222-1222 toxic doses of TCAs 40... Serotonin as a result of MAO-A inhibition ) asenapine transdermal and doxepin both increase QTc interval antidepressant. ) flavoxate and doxepin both increase QTc interval be decreased by ethinyl estradiol 66 % and 69 %.... Serotonergic therapy may be resumed 24 hours after last methylene blue may adverse..., midodrine and phendimetrazine decreases sedation dosage adjustment may be resumed 24 hours after methylene! Other problems keep bupropion dose as low as possible may ; 44 ( 5 Pt )... This survey is being conducted by the doxepin interactions with wellbutrin marketing sciences department which by! Carefully observe the patient, particularly during treatment initiation and dose adjustment carefully observe the patient, particularly during initiation! Terbinafine will increase the level or effect of interaction is not clear, Use caution chemicals ( neurotransmitters ) the...
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