Naylor CD, O'Rourke K, Detsky AS, Baker JP. Mahmassani HA, Switkowski KM, Johnson EJ, et al. Brown L, Rimm EB, Seddon JM, et al. 2013;14(3):1911-8. J Natl.Cancer Inst. View abstract. 2003;133(4):992-998. 2013 Jan;30(1):25-32. Hammond, B. R., Jr. and Fletcher, L. M. Influence of the dietary carotenoids lutein and zeaxanthin on visual performance: application to baseball. Yagi, A., Fujimoto, K., Michihiro, K., Goh, B., Tsi, D., and Nagai, H. The effect of lutein supplementation on visual fatigue: a psychophysiological analysis. View abstract. View abstract. People who dont eat many vegetable or fruits can probably benefit from supplementing with higher doses, as can older adults, smokers and post-menopausal women. View abstract. 1999;19(6):491-495. View abstract. 2011;24 Suppl 1:147-150. Neonatology. 2014 Jan;252(1):63-70. J Matern Fetal Neonatal Med 2020:1-6. 2016;50:34-66. J.Nutr. Li, L., Chen, C. Y., Aldini, G., Johnson, E. J., Rasmussen, H., Yoshida, Y., Niki, E., Blumberg, J. A., Klein, B. E., Klein, R., Palta, M., Bowen, P. E., and Greger, J. L. Serum carotenoids and tocopherols and incidence of age-related nuclear cataract. Cangemi, F. E. TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD. A., Gao, Y. T., Goodman, M. T., Hallmans, G., Helzlsouer, K. J., Hoffman-Bolton, J., Hulten, K., Sesso, H. D., Sowell, A. L., Tamimi, R. M., Toniolo, P., Wilkens, L. R., Winkvist, A., Zeleniuch-Jacquotte, A., Zheng, W., and Hankinson, S. E. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. Olmedilla B, Granado F, Southon S, et al. View abstract. The human body cannot synthesize lutein or zeaxanthin on its own, which means we must obtain these important nutrients from our diets (or, in some cases, supplements). Just like many other types of antioxidants, it is found in brightly colored foods like fruits and vegetables especially leafy greens and types that are deep orange or yellow. View abstract. That is exactly why the lens needs to remain clear and free from the cloudiness that is indicative of cataracts. Cardinault, N., Gorrand, J. M., Tyssandier, V., Grolier, P., Rock, E., and Borel, P. Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects. B., Russell, R. M., and Yeum, K. J. Supplementation with lutein or lutein plus green tea extracts does not change oxidative stress in adequately nourished older adults. View abstract. 2014;52(4):198-205. View abstract. 2013;73(2):236-45. Lutein and its relative zeaxanthin are pigments called carotenoids. View abstract. Williams, M. A., Woelk, G. B., King, I. View abstract. Supplementation with carotenoids, omega-3 fatty acids, and vitamin E has a positive effect on the symptoms and progression of Alzheimer's disease. Am J Perinatol. View abstract. Schupp C, Olano-Martin E, Gerth C, et al. 2011;94(5):1211-1218. Since the plant Hajizadeh-Sharafabad F, Tarighat-Esfanjani A, Ghoreishi Z, Sarreshtedari M. Lutein supplementation combined with a low-calorie diet in middle-aged obese individuals: effects on anthropometric indices, body composition and metabolic parameters. 2001;119(7):1009-1019. 1997;6(8):617-623. Bartlett, H. E. and Eperjesi, F. A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. The association of plasma micronutrients with the risk of cervical dysplasia in Hawaii. Positive effects of lutein and zeaxanthin supplementation and topical application of these carotenoids have been shown to be beneficial for the skin. Lutein uses and benefits include helping prevent eye conditions like macular degeneration and cataracts, skin disorders and skin cancer, several types of cancer, including colon or breast cancer, type 2 diabetes, and heart disease. Along with another vision-boosting carotenoid called zeaxanthin, it is abundant in anti-inflammatory,cancer-fighting foodsincluding kale, broccoli and many other green vegetables, eggs yolks, and citrus fruits all of which studies show help protect the eyes from oxidative stress. 2014 Dec 16;56(1):252-8. Review. Yeum, K. J., Booth, S. L., Sadowski, J. Albanes D, Virtamo J, Taylor PR, et al. View abstract. Dietary lutein and cognitive function in adults: A meta-analysis of randomized controlled trials. 2007;78(5):213-219. 2006;82(5):915-920. View abstract. Pool-Zobel, B. L., Bub, A., Muller, H., Wollowski, I., and Rechkemmer, G. Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods. Am.J.Ophthalmol. Graefes Arch Clin Exp Ophthalmol. Richer, S. P., Stiles, W., Graham-Hoffman, K., Levin, M., Ruskin, D., Wrobel, J., Park, D. W., and Thomas, C. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973. View abstract. Hankinson SE, Stampfer MJ, Seddon JM, et al. 2010;26(6):623-626. Exp Eye Res. Antioxidant status and neovascular age-related macular degeneration. Retina 2010;30(8):1282-1293. View abstract. View abstract. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Lutein has no known severe, serious, moderate, or mild interactions with other drugs. This information does not contain all possible interactions or adverse effects. View abstract. Mares-Perlman JA, Brady WE, Klein BE, et al. Arterioscler.Thromb.Vasc.Biol 1997;17(6):1171-1177. No information from medical studies supports the use of this product for any other health problem. Compared to the control group, diabetic rats taking the supplements experienced lower oxidative stress rates and less damage done to the retina of the eyes, despite being under hyperglycemic conditions. Dani, C., Lori, I., Favelli, F., Frosini, S., Messner, H., Wanker, P., De, Marini S., Oretti, C., Boldrini, A., Massimiliano, C., Bragetti, P., and Germini, C. Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study. View abstract. View abstract. A European multicentre, placebo-controlled supplementation study with alpha-tocopherol, carotene-rich palm oil, lutein or lycopene: analysis of serum responses. View abstract. PLoS One 2019;14(12):e0227048. Knekt P, Ritz J, Pereira MA, et al. Berendschot, T. T., Goldbohm, R. A., Klopping, W. A., van de, Kraats J., van Norel, J., and van Norren, D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Kobayashi J, Tominaga E, Ozeki M, Okubo T, Nakagawa K, Miyazawa T. Randomized controlled trial of a water-soluble formulation of lutein in humans. Murray, I. J., Makridaki, M., van der Veen, R. L., Carden, D., Parry, N. R., and Berendschot, T. T. Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. Mewborn CM, Lindbergh CA, Hammond BR, Renzi-Hammond LM, Miller LS. A. Dietary intake of antioxidants and risk of age-related macular degeneration. A., Liu, C., Tang, G., Krinsky, N. I., and Russell, R. M. Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables. Am.J.Clin.Nutr. In addition to being found within thepigments of oureyes, carotenoids are also present within the skin. 2012;22(2):216-225. Cho, E., Hankinson, S. E., Rosner, B., Willett, W. C., and Colditz, G. A. Mol.Nutr.Food Res. WebIf your eczema ( atopic dermatitis) flare-ups are really bad, oral corticosteroids are one of the treatment options that can help soothe your irritated skin. 1995;36(12):2531-2541. View abstract. View abstract. Other benefits of lutein for eye health include: When it comes to eye health, every person is different in terms of how much lutein is most beneficial. View abstract. Natarajan, L., Rock, C. L., Major, J. M., Thomson, C. A., Caan, B. J., Flatt, S. W., Chilton, J. View abstract. Pickup & Same Day Delivery available on most store items. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degermation: the Veterans LAST study (Lutein Antioxidant Supplement Trial). Robman, L., Vu, H., Hodge, A., Tikellis, G., Dimitrov, P., McCarty, C., and Guymer, R. Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. O'Neill, M. E., Carroll, Y., Corridan, B., Olmedilla, B., Granado, F., Blanco, I., van den, Berg H., Hininger, I., Rousell, A. M., Chopra, M., Southon, S., and Thurnham, D. I. Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies. Dorgan, J. F., Boakye, N. A., Fears, T. R., Schleicher, R. L., Helsel, W., Anderson, C., Robinson, J., Guin, J. D., Lessin, S., Ratnasinghe, L. D., and Tangrea, J. View abstract. The pharmacological effects of quercetin, such as its antioxidant, anti-inflammatory, antiallergic, antiaging, and anticancer activities, as well as its regulating effect on interleukin (IL)-6, IL-8, tumor necrosis factor (TNF), histamine, and tryptase release in mast cells, are well acknowledged [9]. J Sci Food Agric. Djuric, Z., Uhley, V. E., Naegeli, L., Lababidi, S., Macha, S., and Heilbrun, L. K. Plasma carotenoids, tocopherols, and antioxidant capacity in a 12-week intervention study to reduce fat and/or energy intakes. View abstract. Schweiggert, R. M., Mezger, D., Schimpf, F., Steingass, C. B., and Carle, R. Influence of chromoplast morphology on carotenoid bioaccessibility of carrot, mango, papaya, and tomato. Cancer Epidemiol.Biomarkers Prev. Adv Nutr 2021. Hammond BR Jr, Wooten BR, Snodderly DM, et al. Olestra affects serum concentrations of alpha-tocopherol and carotenoids but not vitamin D or vitamin K status in free-living subjects. View abstract. Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial. The effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported mild cognitive complaints: A randomized, double-blind, placebo-controlled study. het Hof, K. H., Tijburg, L. B., Pietrzik, K., and Weststrate, J. Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. Just one drop of this thick cream will moisturize dry hands or itchy eczema spots. 2002;56(7):615-621. J Nutr 2004;134:1887-93. Dherani, M., Murthy, G. V., Gupta, S. K., Young, I. S., Maraini, G., Camparini, M., Price, G. M., John, N., Chakravarthy, U., and Fletcher, A. E. Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population. 2005 - 2023 WebMD LLC. View abstract. View abstract. Gruber M, Chappell R, Millen A, et al. Calendula is often marketed as a treatment for eczema and dermatitis, but there is not much research supporting its effectiveness for these conditions. BMC Ophthalmol 2007;7:3. Correlates of serum lutein + zeaxanthin: findings from the Third National Health and Nutrition Examination Survey. 2002;74(3):371-381. Neutrogena Norwegian Formula Dry Hand Cream. Ophthalmic Surg Lasers Imaging Retina 2016;47(6):528-35. View abstract. Zhang Y, Knol LL, Tan L. Association between dietary lutein/zeaxanthin intake and metabolic syndrome among US females: An analysis of national health and examination surveys 2015-2018. Estimates show that more than 25 million people worldwide are affected by age-related macular degeneration or cataracts, especially people aged 55 and older living in industrialized Western nations. Eichler, O., Sies, H., and Stahl, W. Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst. J.Nutr.Sci.Vitaminol. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. This raises the risk for arteriosclerosis development and clogging of the carotid arteries that can lead to heart attacks. WebThe best antihistamine for eczema is the one that relieves your symptoms. Junghans, A., Sies, H., and Stahl, W. Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. Sasamoto, Y., Gomi, F., Sawa, M., Tsujikawa, M., and Nishida, K. Effect of 1-year lutein supplementation on macular pigment optical density and visual function. Eur.J.Clin.Nutr. Am J Clin Nutr 2004;79 1045-52. Liver Cleanse | Lutein Benefits, Uses, Foods, Side Effects and More - Dr View abstract. View abstract. Beatty, S., Murray, I. J., Henson, D. B., Carden, D., Koh, H., and Boulton, M. E. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative. Bone, R. A., Landrum, J. T., Mayne, S. T., Gomez, C. M., Tibor, S. E., and Twaroska, E. E. Macular pigment in donor eyes with and without AMD: a case-control study. Arch Ophthalmol 2004;122:883-92. 2003;57(9):1135-1140. 2-15-2007;458(2):128-135. Epidemiology 2004;15(6):738-745. Perrone, S., Longini, M., Marzocchi, B., Picardi, A., Bellieni, C. V., Proietti, F., Rodriguez, A., Turrisi, G., and Buonocore, G. Effects of lutein on oxidative stress in the term newborn: a pilot study. 2012;56(1):126-146. Effect of beta-carotene supplementation and lactation on carotenoid metabolism and mitogenic T-lymphocyte proliferation. . 2017;7:CD000254. 2001;74(6):796-802. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. It is certified by the National Eczema Association, meaning it is safe for those with eczema or sensitive skina testament to its mildness. 22. 2001;55(4):252-259. View abstract. J Nutr.Biochem. Several studies Diabetes Care 2022;45(6):1453-1461. Early childhood lutein and zeaxanthin intake is positively associated with early childhood receptive vocabulary and mid-childhood executive function but no other cognitive or behavioral outcomes in project viva. Ito, Y., Wakai, K., Suzuki, K., Tamakoshi, A., Seki, N., Ando, M., Nishino, Y., Kondo, T., Watanabe, Y., Ozasa, K., and Ohno, Y. Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) study. View abstract. View abstract. Invest Ophthalmol.Vis.Sci. Lutein is found in the retina, where it is thought to protect the eye from the View abstract. 4. 2012;90(5):e399-e403. Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study. Paetau, I., Rao, D., Wiley, E. R., Brown, E. D., and Clevidence, B. Cota F, Costa S, Giannantonio C, Purcaro V, Catenazzi P, Vento G. Lutein supplementation and retinopathy of prematurity: a meta-analysis. View abstract. View abstract. Am.J.Clin.Nutr. Ophthalmology 2012;119(11):2290-2297. Arterioscler.Thromb.Vasc.Biol 2004;24(2):313-319. Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses. Online ahead of print. 2006;84(5):971-974. van der Horst-Graat JM, Kok, F. J., and Schouten, E. G. Plasma carotenoid concentrations in relation to acute respiratory infections in elderly people. View abstract. View abstract. Lutein, zeaxanthin and meso-zeaxanthin supplementation associated with macular pigment optical density. Br.J.Ophthalmol. Tan, J. S., Wang, J. J., Flood, V., Rochtchina, E., Smith, W., and Mitchell, P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Long-term supplementation with alpha-tocopherol and beta-carotene and age-related cataract. Lutein and zeaxanthin supplementation in preterm very low-birth-weight neonates in neonatal intensive care units: a multicenter randomized controlled trial. Curr.Pharm.Des 2012;18(34):5577-5589. View abstract. 2012;17(3):3202-3242. Sommerburg, O. G., Siems, W. G., Hurst, J. S., Lewis, J. W., Kliger, D. S., and van Kuijk, F. J. Lutein and zeaxanthin are associated with photoreceptors in the human retina. Rock, C. L., Flatt, S. W., Wright, F. A., Faerber, S., Newman, V., Kealey, S., and Pierce, J. P. Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence. Seddon JM, Ajani UA, Sperduto R, et al. Am J Clin Nutr 1995;62:604-10. Br J Nutr 2021;126(7):1028-1039. J Am Optom.Assoc 1999;70(1):24-36. Am J Clin Nutr 2012;96(2):356-373. View abstract. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. View abstract. Curr Dev Nutr 2021;5(10):nzab123. Optometry 2000;71:147-64.. View abstract. View abstract. Nutr Res 2001;21:797-809. Nutrients. Acta Ophthalmol Scand 1997;75:634-40. Front Aging Neurosci 2017;9:254. Parisi V, Tedeschi M, Gallinaro G, et al. Optometry 2004;75:216-30. Schunemann HJ, Grant BJ, Freudenheim JL, et al. Hammond, B. R., Jr., Fuld, K., and Curran-Celentano, J. Macular pigment density in monozygotic twins. Zhao, X., Aldini, G., Johnson, E. J., Rasmussen, H., Kraemer, K., Woolf, H., Musaeus, N., Krinsky, N. I., Russell, R. M., and Yeum, K. J. Br J Nutr 2004;92(1):113-118. Sumantran, V. N., Zhang, R., Lee, D. S., and Wicha, M. S. Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. J Nutr 2021;151(3):615-627. Martin, K. R., Failla, M. L., and Smith, J. C., Jr. Beta-carotene and lutein protect HepG2 human liver cells against oxidant-induced damage. Thomson, C. A., Stendell-Hollis, N. R., Rock, C. L., Cussler, E. C., Flatt, S. W., and Pierce, J. P. Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer. View abstract. View abstract. Skinmed. Korobelnik JF, Rougier MB, Delyfer MN, et al. Takeda, S., Masuda, Y., Usuda, M., Marushima, R., Ueji, T., Hasegawa, M., and Maruyama, C. Effects of mayonnaise on postprandial serum lutein/zeaxanthin and beta-carotene concentrations in humans. Nolan JM, Power R, Howard AN, et al. 2002;75(3):540-549. B. Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. View abstract. WebLutein is concentrated in the primate retina, where together with zeaxanthin it forms the macular pigment. The supplement used is a product of Wakamoto Pharmaceutical. Bonds DE, Harrington M, Worrall BB, et al. Ophthalmology 2008;115(5):876-883. Cancer Epidemiol.Biomarkers Prev. View abstract. 8-15-2012;92(10):2043-2049. 2012;96(5):1207S-1213S. 2012;25(5):523-527. Some might have a harder time utilizing it and other antioxidants from foods and transporting to tissues within the eyes or other organs. Chong, E. W., Wong, T. Y., Kreis, A. J., Simpson, J. Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A. Arch.Ophthalmol. Product Details: and antioxidant-rich lutein, which protects against blue-light-induced skin aging. View abstract. Front Nutr 2022;9:924997. 2005;15 Suppl 2:S140-S149. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. It seems that people with this disorder might not absorb some carotenoids from food very well and often show low blood levels of lutein. View abstract. Mares-Perlman, J. Goltz, S. R., Campbell, W. W., Chitchumroonchokchai, C., Failla, M. L., and Ferruzzi, M. G. Meal triacylglycerol profile modulates postprandial absorption of carotenoids in humans. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. Public Health Nutr 2020:1-8. Am.J Clin.Nutr 1996;64(4):594-602. Association between dietary carotenoid intakes and the risk of asthma in adults: a cross-sectional study of NHANES, 2007-2012. View abstract. According to some animal studies, higher levels of carotenoids within the blood are linked with fewer problems controlling blood sugar and a lower risk for diabetesor related complications. View abstract. Biosci Biotechnol Biochem 2019;83(12):2372-4. The supplements said to be most helpful for eczema contain one of the following oils: Borage JAMA Intern Med. View abstract. Invest Ophthalmol.Vis.Sci. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Wet Age-Related Macular Degeneration and Vision Loss, An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD). View abstract. Teikari JM, Rautalahti M, Haukka J, et al. Arch Ophthalmol 1995;113:518-23. J Nutr 2004;134:2387-94. You can find lutein supplements in soft-gel capsule form in health food stores and online. Chen J, Jiang W, Shao L, Zhong D, Wu Y, Cai J. Age-Related Eye Disease Study 2 Research Group. Atherosclerosis Risk in Communities. View abstract. Jacques, P. F., Chylack, L. T., Jr., Hankinson, S. E., Khu, P. M., Rogers, G., Friend, J., Tung, W., Wolfe, J. K., Padhye, N., Willett, W. C., and Taylor, A. View abstract. With dry eye disease, also known as dry eye syndrome, your eyes dont make enough lubrication to coat your eyes. This can cause red, itchy, burning, eyes, temporary blurriness, and a feeling as if theres sand in your eye. According to a 2016 study, lutein may help reduce these symptoms. How much lutein do you need? Am J Clin Nutr 2008;87(5):1521-1529. San Giovanni, J. P., Chew, E. Y., Clemons, T. E., Ferris, F. L., III, Gensler, G., Lindblad, A. S., Milton, R. C., Seddon, J. M., and Sperduto, R. D. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. Nutr Cancer 1998;32(3):154-158. Sin, H. P., Liu, D. T., and Lam, D. S. Lifestyle modification, nutritional and vitamins supplements for age-related macular degeneration. Arch Neurol 2000;57:956-63. View abstract. 2011;52(12):9207-9217. View abstract. View abstract. Li J, Abdel-Aal EM. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. An ancillary study of the women's health initiative. View abstract. View abstract. All rights reserved. Nussbaum, J. J., Pruett, R. C., and Delori, F. C. Historic perspectives. View abstract. Snodderly DM. View abstract. Eur.J.Clin.Nutr. Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year. Asia Pac J Clin Nutr 2017;26(3):406-11. Moeller, S. M., Parekh, N., Tinker, L., Ritenbaugh, C., Blodi, B., Wallace, R. B., and Mares, J. WebThe B Vitamins are essential in improving skin conditions such as eczema. 2000;41(11):3322-3326. Carcinogenesis 1997;18(9):1847-1850. Adackapara, C. A., Sunness, J. S., Dibernardo, C. W., Melia, B. M., and Dagnelie, G. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. Carotenoids and colon cancer. USCs observational studies show that people with the highest levels of lutein in the blood experience less plaque buildup in the arteries, while the opposite is also true: The fewer lutein-rich plant foods someone eats, the more clogged their arteries seem to become. J.Ocul.Pharmacol.Ther. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Am J Clin Nutr 2016;103(2):481-94. Cancer Epidemiol.Biomarkers Prev. View abstract. Diet and lifestyle correlates of lutein in the blood and diet. Am.J.Clin.Nutr. 2012;56(2):270-286. Curran-Celentano, J., Hammond, B. R., Jr., Ciulla, T. A., Cooper, D. A., Pratt, L. M., and Danis, R. B. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. J Am Optom Assoc 1999;70:39-47. View abstract. Clin.Nutr. View abstract. Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: pooled results from 5 cohort studies. Arch.Biochem.Biophys. Machida N, Kosehira M, Kitaichi N. Clinical effects of dietary supplementation of lutein with high bio-accessibility on macular pigment optical density and contrast sensitivity: A randomized double-blind placebo-controlled parallel-group comparison trial. A prospective study of carotenoid intake and risk of cataract extraction in US men. Zhou Y, Wang T, Meng Q, Zhai S. Association of carotenoids with risk of gastric cancer: a meta-analysis. Macular yellow pigment. Gastroenterology 1989;97:1033-42. At this time there isnt a general recommendation for daily intake of lutein or zeaxanthin. Hammond, B. R., Jr., Curran-Celentano, J., Judd, S., Fuld, K., Krinsky, N. I., Wooten, B. R., and Snodderly, D. M. Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. Flood, V., Rochtchina, E., Wang, J. J., Mitchell, P., and Smith, W. Lutein and zeaxanthin dietary intake and age related macular degeneration. Am.J.Clin.Nutr. View abstract. View abstract. View abstract. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. Molecules. 2007;125(9):1225-1232. Connolly, E. E., Beatty, S., Loughman, J., Howard, A. N., Louw, M. S., and Nolan, J. M. Supplementation with all three macular carotenoids: response, stability, and safety. Arch.Ophthalmol. 2013;54(3):1781-1788. View abstract. View abstract. Olmedilla, B., Granado, F., Southon, S., Wright, A. J., Blanco, I., Gil-Martinez, E., Berg, H., Corridan, B., Roussel, A. M., Chopra, M., and Thurnham, D. I. Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries. View abstract. Teixeira, V. H., Valente, H. F., Casal, S. I., Marques, A. F., and Moreira, P. A. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. 2002;75(5):503-506. View abstract. J Nutr 1997;127:1636S-45S. Trumbo, P. R. and Ellwood, K. C. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. Invest Ophthalmol.Vis.Sci. Nutrients 2022;14(4):872. Am J Clin Nutr 1999;70(4):490-494. Bartlett, H., Howells, O., and Eperjesi, F. The role of macular pigment assessment in clinical practice: a review. Am J Epidemiol 1999;149:801-9. 2000;46(11):1818-1829. 2006;6:23. View abstract. Richer S, Stiles W, Statkute L, et al. That said, possible lutein and zeaxanthin side effects can include harmless yellowingof the skin calledcarotenemia and an upset stomach/vomiting if you take too much. Bone, R. A., Landrum, J. T., Guerra, L. H., and Ruiz, C. A. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. Xu J, Song C, Song X, Zhang X, Li X. Carotenoids and risk of fracture: a meta-analysis of observational studies. Lyle, B. J., Mares-Perlman, J. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Rock, C. L., Thornquist, M. D., Neuhouser, M. L., Kristal, A. R., Neumark-Sztainer, D., Cooper, D. A., Patterson, R. E., and Cheskin, L. J. View abstract. Kim MK, Ahn SH, Lee-Kim. View abstract. When we eat foods high in lutein or take it in supplement form, its believed to be pretty easily transported around the body, especially to the parts of the eyes called the macula and the lens. Int J Vitam Nutr Res 1998;68:360-5. 12-19-2012;104(24):1905-1916. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Lutein and zeaxanthin status and risk of age-related macular degeneration. Central retinal thickness is positively correlated with macular pigment optical density. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. 2013 Feb 15;5(2):543-51. Nutrients 2017;9(11):1246. To give you some inspiration, here are several recipes to help you out: Lutein appears to be nontoxic and safe for consumption in moderate or even relatively high doses. View abstract. Cochrane Database Syst Rev. A., de Vries, A. J., Goldbohm, R. A., Tijburg, L. B., Kardinaal, A. F., and van Poppel, G. Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. , Switkowski KM, Johnson EJ, et al the women 's health initiative found in the blood diet! 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